Humaner Carboxyl-terminaler PDZ-Ligand von neuronalem Stickstoffmonoxid syn
Gehirnaktivität und Gedächtnisbildung können von den Neuronen des Gehirns gesteuert werden. Enzyme sind an der Regulierung der Stickoxid (NO)-Synthese beteiligt, die für die Gehirnaktivität und die Gedächtnisbildung wichtig ist. Das Adapterprotein, das diese Regulation steuert, heißt NOS1. Es wurde festgestellt, dass die NOS1-Assoziation mit nNOS/NOS1 eine entscheidende Rolle bei der neuronalen Stickoxidproduktion spielt. Stickoxid ist aufgrund seiner Beteiligung an der neuronalen Plastizität ein wichtiges Molekül für Lernen und Gedächtnis. Dieser Artikel beschreibt, was NOS1 tut, wie es es tut und welche Auswirkungen es auf diese Prozesse im Gehirn hat.
Was ist dieses Enzym und was macht es?
Dieses Enzym heißt CREB und steht für cAMP Response Element Binding Protein. Dieses Enzym ist für die Steuerung der Gehirnaktivität und der Gedächtnisbildung verantwortlich. Dies bedeutet, dass wenn etwas passiert, das CREB auslöst, dies zu Veränderungen in der Art und Weise führt, wie das Gehirn funktioniert. Wenn Sie beispielsweise etwas Neues lernen, wird CREB aktiviert und hilft, diese Informationen in Ihrem Gedächtnis zu speichern. Wie aktiviert man CREB auf natürliche Weise? Sie können CREB aktivieren, indem Sie sich körperlich betätigen oder an einer neuen Aktivität wie dem Erlernen einer neuen Sprache oder eines Musikinstruments teilnehmen. Denn wenn Sie bei einer Aktivität härter arbeiten müssen, erhöht das Gehirn seine Aktivität, um zu verstehen, was vor sich geht, und dies führt dazu, dass CREB aktiviert wird.
Kürzlich wurde eine Studie durchgeführt, bei der einer Gruppe von Menschen Bilder gezeigt wurden und sie aufgefordert wurden, sich an sie zu erinnern. Einigen der Gruppen wurden Pillen gegeben, die ihren PEA-Spiegel (Phenylethylamin) erhöhen würden, und anderen wurde nichts gegeben. Was die Forscher herausfanden, war, dass diejenigen, die PEA genommen hatten, sich an mehr Bilder erinnerten, weil ihre Gedächtnisleistung aufgrund ihres erhöhten Niveaus zunahm
Wie kann ein Mangel oder eine Überproduktion dieses Enzyms Probleme verursachen?
Das Enzym, das die Gehirnaktivität und die Gedächtnisbildung steuert, ist ein wichtiger Teil des Gehirns, der hilft, die Aktivität und die Gedächtnisbildung zu kontrollieren. Ein Mangel oder eine Überproduktion dieses Enzyms kann jedoch zu Problemen führen. Ein Mangel an diesem Enzym kann zu Problemen bei der Gedächtnisbildung und einer Abnahme der Gehirnaktivität führen. Eine Überproduktion dieses Enzyms kann zu einer Zunahme der Gehirnaktivität und zu Problemen bei der Kontrolle dieser Aktivität führen. Wie kann dieses Enzym kontrolliert werden, um sicherzustellen, dass es nicht zu einer Überproduktion kommt? Die Aktivität des Enzyms, das die Gehirnaktivität und die Gedächtnisbildung steuert, kann durch die Stimulierung der Produktion von Alpha-Aminobuttersäure, einem Neurotransmitter im Gehirn, der als GABA freigesetzt wird, gesteuert werden. Je mehr Alpha-Aminobuttersäure produziert wird, desto geringer ist die Aktivität dieses Enzyms und desto geringer sind die Gehirnaktivität und die Gedächtnisbildung. Ein Mangel an Alpha-Aminobuttersäure führt zu einer Erhöhung der Gehirnaktivität, wenn GABA vorhanden ist, da GABA die Produktion von Alpha-Aminobuttersäure nicht stimuliert. Ein Mangel an GABA oder eine Hemmung seiner Funktion würde jedoch zu einem führen
Woher wissen wir, ob jemand zu viel oder zu wenig Enzymaktivität hat?
- Es gibt verschiedene Möglichkeiten, die Enzymaktivität zu messen. Die gebräuchlichste Methode ist die Messung der Produktmenge, die produziert wird, wenn das Enzym aktiv ist. Dies kann mit einem Spektrophotometer gemessen werden. Ein Spektrophotometer wird verwendet, um zu messen, wie viel Licht durch die Probe geht und wie viel dieses Lichts vom Produkt absorbiert wird.
- Die Menge der Absorption sagt aus, wie viel Produkt sich gebildet hat. Dies wird Absorption genannt und auf einer Skala von 0-1.000 gemessen. Eine Extinktion von 0 bedeutet, dass kein Produkt gebildet wurde, während eine Extinktion von 1.000 bedeutet, dass unter diesen Bedingungen das gesamte mögliche Produkt hergestellt wurde.
- Die Geschwindigkeit, mit der diese Reaktion auftritt, hängt von der Konzentration jedes Reaktanten und der Enzymkonzentration ab. Je mehr Enzyme vorhanden sind, desto schneller ist die Reaktionsgeschwindigkeit. Ebenso verdoppeln wir die Reaktionsgeschwindigkeit, wenn wir die Konzentration eines Reaktanten (z. B. Glucose) verdoppeln.
- Um eine bessere Vorstellung davon zu bekommen, wie Enzyme und ihre Konzentrationen diesen Assay beeinflussen, müssen wir einige weitere Begriffe einführen . Der Enzym-Substrat-Komplex (ES) entsteht, wenn ein Enzym an sein Substrat bindet. Dieses ES stellt dann ein Produkt her, indem es andere Moleküle (als Katalyseprodukte bezeichnet) auseinanderbricht. Diese Produkte werden als Substrate der Katalyse bezeichnet und sind oft kleiner als das ursprüngliche Molekül.
- Der erste Schritt bei der Messung der Fähigkeit eines Enzyms, ein Produkt herzustellen, besteht tatsächlich darin, die Menge des Enzym-Substrat-Komplexes zu messen, der sich während der Inkubation bildet, BEVOR die Produktbildung begonnen hat.
Was kann getan werden, um die Produktion dieses Enzyms zu erhöhen oder zu verringern?
Über das Enzym, das die Gehirnaktivität und die Gedächtnisbildung steuert, ist noch vieles unbekannt. Wissenschaftler haben jedoch die Theorie aufgestellt, dass es Dinge gibt, die getan werden können, um seine Produktion zu erhöhen oder zu verringern. Zum Beispiel wird angenommen, dass der Verzehr von Lebensmitteln mit hohem Antioxidantiengehalt die Produktion dieses Enzyms steigern kann. Auf der anderen Seite könnte die Exposition gegenüber Stress oder Traumata zu einer Verringerung seiner Produktion führen. Der Prozess der Gedächtnisbildung ist ein komplexer Vorgang, an dem viele verschiedene Teile des Gehirns beteiligt sind. Es wird angenommen, dass durch die Untersuchung des Enzyms namens Proteinkinase C die Mechanismen hinter der Gedächtnisbildung klarer werden können.Dies liegt daran, dass dieses Enzym eine so wichtige Rolle bei der Bildung von Erinnerungen spielt. Daher wäre es äußerst hilfreich zu wissen, welche Ereignisse dazu führen, dass seine Produktion zunimmt oder abnimmt, und ob es Lebensmittel gibt, die seine Produktion steigern können. Auswirkungen von Alkohol auf PKC
Laut einem Artikel in Alcoholism: Clinical & Experimental Research entdeckten Forscher, dass Alkoholkonsum das Enzym PKA hemmt, indem es seine Produktion durch Hemmung der Proteinkinase A (PKA) blockiert. Die Forscher fanden auch heraus, dass die Aktivität der Proteinkinase C auch durch Alkoholkonsum gehemmt wird (Alcoholism: Clinical & Experimental Research, 1990). Daher hat sich gezeigt, dass Alkoholkonsum die Gedächtnisbildung hemmen kann. Eine im American Journal of Physiology – Endocrinology and Metabolism veröffentlichte Studie kam jedoch zu einem anderen Ergebnis. In dieser Studie fanden die Forscher heraus, dass das Trinken moderater Mengen Alkohol das Gedächtnis verbessert und die Proteinkinase-C-Spiegel erhöht (American Journal of Physiology – Endocrinology and Metabol
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CAPON (Carboxyl-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein, NOS1AP, KIAA0464) |
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Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody |
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Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody |
|||
| abx302365-50g | Abbexa | 50 µg | 250 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (AP) |
|||
| MBS6132617-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (AP) |
|||
| MBS6132617-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (PE) |
|||
| MBS6159132-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (PE) |
|||
| MBS6159132-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (FITC) |
|||
| MBS6148526-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (FITC) |
|||
| MBS6148526-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (HRP) |
|||
| MBS6153829-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (HRP) |
|||
| MBS6153829-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (Biotin) |
|||
| MBS6143223-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (Biotin) |
|||
| MBS6143223-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (AP) |
|||
| MBS6387260-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (AP) |
|||
| MBS6387260-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) APC |
|||
| MBS6387261-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) APC |
|||
| MBS6387261-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (Biotin) |
|||
| MBS6387262-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (Biotin) |
|||
| MBS6387262-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (FITC) |
|||
| MBS6387263-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (FITC) |
|||
| MBS6387263-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (HRP) |
|||
| MBS6387264-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (HRP) |
|||
| MBS6387264-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (PE) |
|||
| MBS6387270-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (PE) |
|||
| MBS6387270-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) APC |
|||
| MBS6137920-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) APC |
|||
| MBS6137920-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| EK4811 | SAB | 96 tests | 599 EUR |
Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888294-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 4080 EUR |
Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888294-48StripWells | MyBiosource | 48-Strip-Wells | 390 EUR |
Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888294-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 2220 EUR |
Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888294-96StripWells | MyBiosource | 96-Strip-Wells | 520 EUR |
Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS9428637-5x96Tests | MyBiosource | 5x96Tests | 2820 EUR |
Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS9428637-96Tests | MyBiosource | 96Tests | 615 EUR |
Mouse Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888293-10x96StripWells | MyBiosource | 10x96-Strip-Wells | 4080 EUR |
Mouse Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888293-48StripWells | MyBiosource | 48-Strip-Wells | 390 EUR |
Mouse Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888293-5x96StripWells | MyBiosource | 5x96-Strip-Wells | 2220 EUR |
Mouse Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein ELISA Kit |
|||
| MBS2888293-96StripWells | MyBiosource | 96-Strip-Wells | 520 EUR |
NOS1AP, ID (NOS1AP, CAPON, KIAA0464, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein) |
|||
| MBS646062-02mL | MyBiosource | 0.2mL | 695 EUR |
NOS1AP, ID (NOS1AP, CAPON, KIAA0464, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein) |
|||
| MBS646062-5x02mL | MyBiosource | 5x0.2mL | 2975 EUR |
NOS1AP, ID (NOS1AP, CAPON, KIAA0464, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein) (AP) |
|||
| MBS6326005-02mL | MyBiosource | 0.2mL | 980 EUR |
NOS1AP, ID (NOS1AP, CAPON, KIAA0464, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein) (AP) |
|||
| MBS6326005-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
NOS1AP, ID (NOS1AP, CAPON, KIAA0464, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein) (PE) |
|||
| MBS6326015-02mL | MyBiosource | 0.2mL | 980 EUR |
NOS1AP, ID (NOS1AP, CAPON, KIAA0464, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein) (PE) |
|||
| MBS6326015-5x02mL | MyBiosource | 5x0.2mL | 4250 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (HRP) |
|||
| abx317052-100g | Abbexa | 100 µg | 362.5 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (HRP) |
|||
| 20-abx317052 | Abbexa |
|
|
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (HRP) |
|||
| abx317052-20g | Abbexa | 20 µg | 162.5 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (HRP) |
|||
| abx317052-50g | Abbexa | 50 µg | 250 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (FITC) |
|||
| abx317053-100g | Abbexa | 100 µg | 362.5 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (FITC) |
|||
| 20-abx317053 | Abbexa |
|
|
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (FITC) |
|||
| abx317053-20g | Abbexa | 20 µg | 162.5 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (FITC) |
|||
| abx317053-50g | Abbexa | 50 µg | 250 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 405) |
|||
| MBS6191481-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 405) |
|||
| MBS6191481-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 550) |
|||
| MBS6212831-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 550) |
|||
| MBS6212831-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 750) |
|||
| MBS6234181-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 750) |
|||
| MBS6234181-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 405) |
|||
| MBS6387265-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 405) |
|||
| MBS6387265-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 490) |
|||
| MBS6387266-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 490) |
|||
| MBS6387266-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 550) |
|||
| MBS6387267-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 550) |
|||
| MBS6387267-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 650) |
|||
| MBS6387268-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 650) |
|||
| MBS6387268-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 750) |
|||
| MBS6387269-01mL | MyBiosource | 0.1mL | 920 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 750) |
|||
| MBS6387269-5x01mL | MyBiosource | 5x0.1mL | 3990 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 490) |
|||
| MBS6202156-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 490) |
|||
| MBS6202156-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 650) |
|||
| MBS6223506-01mL | MyBiosource | 0.1(mL | 875 EUR |
NOS1AP (CAPON, KIAA0464, Carboxyl-terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein, C-terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein, Nitric Oxide Synthase 1 Adaptor Protein) (MaxLight 650) |
|||
| MBS6223506-5x01mL | MyBiosource | 5x0.1mL | 3800 EUR |
ELISA Kit for Rat Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
|||
| E8789r | EIAab | 96T | 387.4 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (Biotin) |
|||
| abx317054-100g | Abbexa | 100 µg | 362.5 EUR |
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein (NOS1AP) Antibody (Biotin) |
|||
| 20-abx317054 | Abbexa |
|
|
Fazit
Es ist klar, dass das Enzym PDE4 essentiell für die Steuerung der Gehirnaktivität und der Gedächtnisbildung ist. Dieses Enzym ist für den Abbau von cAMP verantwortlich, einem Molekül, das bei vielen wichtigen Prozessen im Gehirn eine Rolle spielt. Ohne PDE4 würde sich cAMP auf Werte aufbauen, die für Zellen toxisch wären, und dies würde zu Problemen mit dem Gedächtnis und anderen kognitiven Funktionen führen. Daher könnten PDE4-Hemmer möglicherweise zur Behandlung von Erkrankungen wie der Alzheimer-Krankheit und anderen Formen von Demenz eingesetzt werden.