• Juni 13, 2021

Human alpha 1-Antichymotrypsin ELI


Quality level: 200

Biological source: human plasma

Test: ≥60% (biuret)

Form: salt-free lyophilized powder

Application(s): inhibition test: adequate

Storage temperature: 2-8 ° C

Genetic information

human … ELA2 (1991), ELANE (1991), SERPINA1 (5265)



25, 100, 500 mg in a glass bottle

Biochemical / Physiological Actions

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Equimolar effective concentration with proteinase. The effects of inherited α1-antitrypsin deficiency and certain autoimmune conditions result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of type 1 diabetes.

≤10 mg will inhibit 1.0 mg of trypsin with an activity of 10,000 BAEE units per mg of protein. ≤10 mg will inhibit approx. 1.0 mg of α-chymotrypsin with the activity of 40-50 BTEE units per mg of protein.


Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at -80 ° C, but must not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of the methionine residue of the active site.

Preparation note

Chromatographically prepared and partially purified.

Schreibe einen Kommentar

Deine E-Mail-Adresse wird nicht veröffentlicht. Erforderliche Felder sind mit * markiert